Integration of Mutation and Chromosomal Damage Endpoints into 28-Day Repeat Dose Toxicology Studies
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چکیده
منابع مشابه
Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies.
Two endpoints of genetic toxicity, mutation at the X-linked Pig-a gene and chromosomal damage in the form of micronucleated reticulocytes (MN-RETs), were evaluated in blood samples obtained from 28-day repeat-dosing studies typical of those employed in toxicity evaluations. Male Wistar Han rats were treated at 24-h intervals on days 1 through 28 with one of five prototypical genotoxicants: N-et...
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متن کامل28 Toxicology
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Biomonitoring: Integration of biological endpoints into chemical monitoring*
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2010
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfq070